Eating disorders

Highlights

Eating Disorders Overview

Complications of Bulimia Nervosa

People with bulimia nervosa may make themselves vomit or use laxatives or diuretics to rid themselves of consumed calories. Many medical problems are directly associated with purging behavior, including:

Complications of Anorexia Nervosa

Anorexia nervosa can increase the risk for serious health problems, such as:

Treatment of Bulimia Nervosa

Treatment of Anorexia Nervosa

First Drug Approved for Binge-Eating Disorder

In 2015, the FDA approved lisdexamfetamine dimesylate (Vyvanse) to treat binge-eating disorder. It is the first FDA-approved medication to treat this condition. Lisdexamfetamine is a central nervous stimulant that was previously approved to treat attention-deficit hyperactivity disorder.

Introduction

Eating disorders are psychological problems marked by an obsession with food and weight. The main types of eating disorders are:

Anorexia Nervosa

There are three main features of anorexia nervosa:

Anorexia nervosa has two subtypes, based on a person's behavior during the past 3 months:

Bulimia Nervosa

Bulimia nervosa is characterized by cycles of bingeing and purging:

Binge-Eating Disorder

Bingeing without purging is characterized as uncontrolled overeating (binge eating) with the absence of purging behaviors, such as vomiting or laxative abuse (used to eliminate calories). Binge eating usually leads to becoming overweight.

Binge eating is characterized by:

Causes

There is no single cause for eating disorders. Although concerns about weight and body shape play a role in all eating disorders, the actual cause of these disorders appears to involve many factors, including those that are genetic and neurobiological, cultural and social, and behavioral and psychological.

Genetic Factors

Anorexia is much more common in people who have relatives with the disorder. Studies of twins show they have a tendency to share specific eating and weight disorders (anorexia nervosa, bulimia nervosa, and obesity). Researchers have identified specific chromosomes that may be associated with bulimia and anorexia.

Biological Factors

The body's hypothalamic-pituitary-adrenal axis (HPA) may be important in eating disorders. This complex system originates in the following regions in the brain:

Hypothalamus

Click the icon to see an image of the hypothalamus.

The HPA system releases certain neurotransmitters (chemical messengers in the brain) that regulate stress, mood, and appetite. Three neurotransmitters, serotonin, norepinephrine, and dopamine, may play particularly important roles in eating disorders.

Serotonin is involved with well-being, anxiety, and appetite (among other traits). Norepinephrine is a stress hormone. Dopamine is involved in reward-seeking behavior. Imbalances with serotonin and dopamine may explain in part why people with anorexia do not experience a sense of pleasure from food and other typical comforts.

Psychological Factors

Many people with eating disorders also experience depression, anxiety disorders, and obsessive-compulsive disorder (OCD). It is not clear if these disorders, particularly OCD, cause the eating disorders, increase susceptibility to them, or share common biologic causes.

Obsessive-Compulsive Disorder (OCD): OCD is a mental health disorder that may occur in up to two-thirds of people with anorexia and up to a third of people with bulimia. Some experts believe that eating disorders are variants of OCD.

Obsessions are recurrent or persistent mental images, thoughts, or ideas, which may result in compulsive behaviors, which are repetitive, rigid, and self-prescribed routines. People with anorexia and OCD may become obsessed with exercise, dieting, and food. They often develop compulsive rituals (weighing each bit of food, cutting it into tiny pieces, or putting it into small containers).

Body Dysmorphic Disorder (BDD): BDD is related to OCD. It is a compulsive disorder that involves a distorted obsession with finding fault with one's body. BDD is often associated with anorexia or bulimia, but it can also occur without any eating disorder.

Muscle dysmorphia is a form of body dysmorphic disorder in which the obsession involves musculature and muscle mass. It tends to occur in men who perceive themselves as being underdeveloped or "puny," which results in excessive body building, preoccupation with diet, use of anabolic steroids, and eating disorders.

Cultural Factors

Cultural values that emphasize only certain types of body shapes as desirable or normal contribute to eating disorders. The media plays a role in promoting these unrealistic expectations for body image and a distorted cultural drive for thinness. At the same time, cheap and high-caloric foods are aggressively marketed. Such messages are contradictory and confusing.

Risk Factors

Age

Anorexia nervosa and bulimia nervosa occur most often in adolescents and young adults. These disorders rarely begin before puberty or after age 40. Binge eating disorder typically begins during adolescence or young adulthood, but it can also first develop in older adults.

Gender

Eating disorders occur predominantly among girls and women. About 90 to 95% of people with anorexia nervosa, and about 80% of people with bulimia nervosa, are female.

Race and Ethnicity

Most studies of individuals with eating disorders have focused on Caucasian middle-class females. However, eating disorders can affect people of all races and socioeconomic levels.

Personal History

Some people with eating disorders are survivors of emotional or physical trauma. These stressful life experiences may have included physical or sexual abuse, painful loss of loved ones, or having lived through war or natural disasters. Bullying may contribute to eating disorders, especially if the ridicule and humiliation are directed at the victim's weight and body shape.

Research indicates that exposure to trauma, and development of post-traumatic stress disorder (PTSD), may increase the risk for eating disorders.

Personality Traits

People with eating disorders tend to share certain personality and behavioral traits including low self-esteem and obsessions with weight and body shape and size. There are also differences depending on the type of eating disorder:

Dieting

A history of dieting or food restriction is associated with increased risk for eating disorders. Although there is no evidence that families or parents cause eating disorders, research suggests that parental conversations that focus on weight and size may increase the risk for eating disorders. In contrast, engaging adolescents in conversations about healthy eating may help prevent eating disorders.

Exercise and Sports

Excessive exercise is associated with many cases of anorexia (and, to a lesser degree, bulimia). In young female athletes, exercise and low body weight postpone puberty, allowing girls to retain a muscular boyish shape without the normal accumulation of fatty tissues in breasts and hips that may blunt their competitive edge. Coaches and teachers may compound the problem by overemphasizing calorie counting and loss of body fat.

The "female athlete triad" syndrome is a combination of eating disorders, amenorrhea (absent or irregular menstruation), and osteoporosis (loss of bone mineral density). However, eating disorders also affect male athletes. Male wrestlers are particularly notorious for using a method called weight-cutting for rapid weight loss. This process involves food restriction and fluid depletion by using steam rooms, saunas, laxatives, and diuretics.

Complications

Eating disorders are very serious illnesses that have wide range of effects on the body and mind. They are frequently associated with a number of other medical problems, ranging from frequent infections and general poor health to life-threatening conditions.

Gastrointestinal Complications

Purging can cause extensive damage throughout the digestive tract. Complications include:

Heart Complications

Heart disorders are the most common medical causes of death in people with severe anorexia nervosa. The effects of anorexia on the heart include:

Bradycardia

Bradycardia is a slowness of the heartbeat, usually at a rate under 60 beats per minute (normal resting rate is 60 to 100 beats per minute).

Starvation, binge eating, and purging can cause damage to many of the body's organs including the kidneys, lungs, and liver. Severe anorexia nervosa can cause multi-organ failure.

Hormonal Complications

Starvation can cause serious hormonal changes, which may have severe health consequences. Hormones affected include:

In women, these hormonal abnormalities can cause irregular or absent menstruation (amenorrhea). This menstrual problem can occur early on in anorexia, even before severe weight loss. Over time hormonal imbalances can lead to infertility and pregnancy complications, thinning bones (osteoporosis), and other problems.

In children and adolescents with eating disorders, hormonal complications can interfere with normal bone development and growth.

Bone Complications

Nearly all women with anorexia experience osteopenia (loss of bone calcium), and many have osteoporosis (more advanced loss of bone density). Up to two-thirds of children and adolescent girls with anorexia fail to develop strong bones during their critical growing period. Boys with anorexia also suffer from stunted growth. The less a person weighs, the more severe the bone density loss. People who binge-purge face an even higher risk for bone density loss.

Bone density loss in women is mainly due to low estrogen levels that occur with anorexia. Other biologic factors in anorexia also may contribute to bone density loss, including high levels of stress hormones (which impair bone growth) and low levels of calcium, certain growth factors, and DHEA (a weak male hormone). Weight gain, unfortunately, does not completely restore bone. Only achieving regular menstruation can protect against permanent bone density loss. The longer the eating disorder persists the more likely the bone density loss will be permanent.

Testosterone levels decline in boys as they lose weight, which also can affect their bone density. In boys with anorexia, weight restoration produces some catch-up growth, but it may not produce full growth.

Blood Complications

Anemia (reduced number of red blood cells) is a common result of malnutrition and starvation. A particularly serious blood problem is caused by severely low levels of vitamin B12. If anorexia becomes extreme, the bone marrow dramatically reduces its production of blood cells, a life-threatening condition called pancytopenia.

Teeth and Skin Complications

Tooth erosion, cavities, mouth sores, and gum problems are common in people who purge. The stomach acid caused by forced vomiting erodes tooth enamel and dries out the saliva glands.

Dehydration affects people with bulimia nervosa and anorexia nervosa. It can cause dry, flaky skin and brittle hair. People may lose hair on the scalp, but grow a layer of downy hair elsewhere, which is the body's attempt to try to stay warm.

Neurological Complications

Neurological conditions associated with severe anorexia nervosa include:

Imaging scans indicate that parts of the brain physically shrink (atrophy) during anorexic states. Weight gain helps many people recover brain function, but some damage may be permanent.

Emotional Complications

Anxiety disorders and depression are common in people with eating disorders. They are also at higher risk for substance abuse including smoking (to help prevent weight gain), alcohol, and drug abuse. In addition to illegal drugs, people with eating disorders often abuse over-the-counter laxatives, diuretics, appetite suppressants, and drugs that induce vomiting (such as ipecac). Some people with anorexia nervosa are at risk for suicidal behavior.

Diabetes Complications

Eating disorders are particularly serious for people with diabetes (type 1 or type 2).

Low blood sugar (hypoglycemia) is a danger for anyone with anorexia, but it poses a particular risk for people with diabetes, especially those who take supplemental insulin. If people do not take their insulin, dangerous high blood sugar (hyperglycemia) can occur. Unfortunately, people with eating disorders may skip or reduce their daily insulin in order to decrease their body's utilization of calories.

Extremely high blood sugar levels can cause life-threatening complications. They include diabetic ketoacidosis, a condition in which acidic chemicals (ketones) accumulate in the body. This condition can lead to coma and death.

Symptoms

Symptoms Specific to Anorexia Nervosa

The main symptom of anorexia nervosa is major weight loss from excessive and continuous dieting.

Behavioral symptoms and warning signs of anorexia may include:

Other symptoms of anorexia may include:

Symptoms Specific to Bulimia Nervosa

Symptoms and signs of binge eating and purging behaviors may include:

Diagnosis

The first step toward a diagnosis is to admit the existence of an eating disorder. Oftentimes, people with eating disorders deny they have a problem.

According to the American Psychiatric Association, people with eating disorders (especially anorexia nervosa) frequently lack insight into their condition. Therefore, health care providers may turn to family members for information regarding weight loss and additional symptoms. Because people who purge tend to have complications with their teeth and gums, dentists can play a role in identifying eating disorders.

Measuring Body Mass Index

A health care provider will evaluate a person's body mass index (BMI). The BMI is a measurement of body fat. It is derived by multiplying a person's weight in pounds by 703 and then dividing it twice by the height in inches. (BMI calculators are available online.)

BMI ranges are:

For example, a woman who is 5'5" and weighs 125 pounds has a healthy BMI of 21. A woman at the same height who weighs 90 pounds would have a dangerously low BMI of 15.

Diagnostic Criteria for Eating Disorders

A health care provider will carefully evaluate a person's medical history, symptoms, and mental health. The provider will ask questions about eating behaviors and any family history of eating disorders or weight issues.

Eating disorders are diagnosed based on criteria from the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM). [See Introduction section of this report for a complete list of diagnostic criteria.] The criteria outline specific behaviors and symptoms that define anorexia nervosa, bulimia nervosa, binge-eating disorder, and other eating disorders.

Diagnosing Complications of Eating Disorders

The provider will check for any serious complications of eating disorders. Tests may include:

Screening Tests

Various questionnaires are available for screening. The Eating Disorders Examination (EDE), which is used by a clinician to interview the person, and the self-reported Eating Disorders Examination-Questionnaire (EDE-Q) are considered the best tests for diagnosing eating disorders and assessing specific features (such as vomiting or laxative use).

Another test is called the SCOFF questionnaire. Answering yes to two of these questions is a strong indicator of an eating disorder:

Do you make yourself Sick because you feel uncomfortably full?

Do you worry you have lost Control over how much you eat?

Have you recently lost more than One stone's worth of weight (14 pounds) in a 3-month period?

Do you believe yourself to be Fat when others say you are too thin?

Would you say that Food dominates your life?

Treatment

Treatment goals for eating disorders include:

A multidisciplinary team approach with consistent support and counseling is essential for long-term recovery. Depending on the severity and type of eating disorder, team members may include:

All health care providers should be experienced in treating eating disorders.

General Treatment Approaches

Eating disorders are nearly always treated with some form of psychological treatment. Depending on the disorder and the individual, certain psychotherapeutic approaches may work better than others.

Nutritional rehabilitation counseling is essential for recovery. It can help people develop structured meal plans and healthy eating and weight management. In anorexia nervosa, family-based therapies that involve a parent's assistance in feeding can be very helpful.

Medications such as selective serotonin reuptake inhibitor (SSRI) antidepressants may be added to psychotherapy for bulimia, but there is limited evidence that these or other drugs have any significant effect on anorexia nervosa.

Although anorexia nervosa generally presents more treatment challenges than bulimia nervosa, long-term studies show recovery in many people treated for anorexia. Studies indicate that a majority of people with bulimia nervosa, and up to half of people with anorexia nervosa, are free from eating disorders within 10 years of treatment.

Choosing a Treatment Setting

The person's overall physical condition, psychology, behavior, social circumstances, and health insurance determine the type of treatment facility, such as inpatient hospitalization, residential hospitalization, partial hospitalization, or outpatient care. People and their families should discuss with their doctors the various options available and how structured and intense the treatment should be.

Hospitalization may be required when:

When severe metabolic or medical problems occur, people with eating disorders may need to be hospitalized either voluntarily or involuntarily. A variety of partial hospitalization or day care programs are also available.

People with severe anorexia nervosa may need 10 to 12 weeks of hospitalization with full nutritional support in order to reach a healthy body weight.

Treatment for Anorexia Nervosa

Nutrition rehabilitation and psychotherapy are the cornerstones of anorexia nervosa treatment.

Nutritional Interventions

The first step for treatment is to help the person reach a healthy weight. Nutritional intervention is essential to achieve weight gain, normalize eating patterns and perceptions of hunger and fullness, and improve overall health. A registered dietician can help design an eating plan and teach skills for choosing nutritional meals.

Goals for weight gain are 2 to 3 pounds a week for hospitalized people and 0.5 to 1 pound a week for outpatients. People typically begin with a calorie count as low as 1,000 to 1,600 calories a day, which is then gradually increased to 2,000 to 3,500 calories a day.

Side effects may accompany the early stages of weight gain. People may initially experience psychological symptoms such as intensified anxiety and depression, as well as physical symptoms such as fluid retention and constipation. These symptoms decrease as the weight is maintained.

Enteral and Parenteral Nutrition: People who are hospitalized for severe malnutrition may require tube feeding (enteral) or intravenous feeding (parenteral) nutrition. Enteral nutrition uses feeding tubes that pass through the nose to the stomach or through the abdominal skin to the stomach. Parenteral nutrition involves inserting a needle into the vein and infusing fluids containing nutrients directly into the bloodstream.

Intravenous feedings must be administered slowly and carefully to avoid refeeding syndrome. This condition causes dangerous hormonal and metabolic fluctuations that affect fluid and electrolyte balances. If not controlled, it can result in heart failure. The person's heart rhythms, and phosphate and magnesium levels, must be carefully monitored.

The Maudsley Approach: For adolescent and other younger people in the early stages of anorexia nervosa, the Maudsley approach to refeeding may be effective. The Maudsley approach is a type of family therapy that enlists the family as a central player in the person's nutritional recovery. Parents take charge of planning and supervising all of their child's meals and snacks. As recovery progresses, the child gradually takes on more personal responsibility for determining when and how much to eat. Weekly family meetings and family-based counseling are also part of this therapeutic approach.

Psychotherapy and Medications for Anorexia Nervosa

Psychotherapy: Psychotherapy is the main therapeutic approach for anorexia nervosa. Psychotherapy may be given in an individual, group, or family setting. Family therapy is an important component of anorexia treatment for children and adolescents.

Individuals usually begin with a form of psychodynamic psychotherapy that provides an empathetic setting, addresses unresolved emotional issues, and rewards positive efforts towards weight gain. Some people also benefit from incorporating approaches such as art therapy. After weight is restored, cognitive behavioral therapy techniques may be helpful.

Antidepressants: Studies have not reported benefits for treating anorexia nervosa with selective serotonin reuptake inhibitors (SSRIs), the antidepressants that are often useful for people with bulimia. A few studies suggest that these drugs could be useful for people with anorexia nervosa who also have obsessive-compulsive disorder (OCD).

Nutritional Supplements: People with anorexia nervosa often have deficiencies in important vitamins and minerals such as vitamins B12, C, and D and minerals calcium, iron, zinc, and magnesium. Vitamin and mineral supplements may be recommended.

Exercise in Recovery

The role of exercise in recovery is complex for those with anorexia, since excessive exercise is often a component of the original disorder. Exercise should not be performed if severe medical problems still exist or if the person has not gained significant weight. The goal of exercise should be on improving physical fitness and health, not on burning off calories.

Treatment for Bulimia and Binge-Eating Disorder

Treatment for bulimia nervosa or binge-eating disorder takes a multidisciplinary approach, which may include:

Outpatient treatment is recommended for most people with these eating disorders. People with bulimia nervosa rarely need hospitalization except under the following circumstances:

Medications for Bulimia Nervosa and Binge-Eating Disorder

Antidepressants: The most common antidepressants prescribed for bulimia nervosa or binge-eating disorder are selective serotonin reuptake inhibitors (SSRIs) such as:

Studies are mixed, however, on whether SSRIs offer an additional advantage in reducing binge-eating compared to CBT. Fluoxetine has been approved for bulimia and is considered the drug of choice, although some studies suggest that other SSRIs work just as well. Other types of antidepressants, such as tricyclics, MAO inhibitors, and bupropion (Wellbutrin, generic), carry more risks of side effects than SSRIs and do not appear to be effective for treatment of bulimia.

Antidepressants may increase the risks for suicidal thoughts and actions during the first few months of treatment. In particular, adolescents and young adults should be carefully monitored during this time period for any changes in behavior.

Lisdexamfetamine: In 2015, the FDA approved lisdexamfetamine dimesylate (Vyvanse) to treat binge-eating disorder. It is the first FDA-approved medication to treat this condition. Lisdexamfetamine is a central nervous stimulant that was previously approved to treat attention-deficit hyperactivity disorder. In clinical trials, the drug reduced the number of binge eating episodes and obsessive-compulsive eating behaviors. Side effects include dry mouth, insomnia, increased heart rate, and anxiety. This drug is classified as a controlled substance because it has a high potential for abuse and dependency

Topiramate: The antiepileptic drug topiramate (Topamax, generic) has been shown in studies to reduce bingeing and purging episodes in people with bulimia nervosa and binge-eating disorder. However, this drug can cause serious side effects including birth defects. In addition, because people tend to lose weight while taking topiramate, it should not be used by those who have low or even normal body weight.

Psychotherapy

Eating disorders are nearly always treated with some form of psychotherapy. Depending on the individual and the disorder, certain psychological approaches may work better than others.

Cognitive-Behavioral Therapy

Cognitive-behavioral therapy (CBT) works on the principle that a pattern of false thinking and belief about one's body can be recognized objectively and altered, thereby changing the response and eliminating the unhealthy reaction to food. CBT is proven to be particularly effective for bulimia nervosa.

A CBT approach for bulimia nervosa may include:

Interpersonal Therapy

Interpersonal therapy deals with depression or anxiety that might underlie the eating disorders along with social factors that influence eating behavior. This therapy does not deal with weight, food, or body image at all.

The goals are to:

Motivational Enhancement Therapy

Motivational enhancement therapy is another form of behavioral therapy that uses an empathetic approach to help people understand and change their behaviors concerning food. It may be offered in an individual or group setting.

Focal Psychodynamic Therapy

Focal psychodynamic therapy (FPT) focuses on how unresolved early childhood experiences may play a role in the later development of eating disorders. The therapist helps the patient gain insight into how certain stresses and conflicts in a person's early years may have created emotional patterns and negative ways of thinking that lie beneath the eating disorder. This therapy has been found to be helpful in treating people with anorexia nervosa.

Dialectical Behavioral Therapy

Dialectical behavioral therapy (DBT) incorporates mindfulness, acceptance skills, interpersonal skills, and emotional regulation. It focuses on the role of emotions and how people may use food as an inappropriate coping strategy for dealing with emotional distress. A DBT therapist will work with people to help them find more effective ways to deal with emotional stressors. DBT appears to be an effective psychotherapy for people with bulimia nervosa and binge eating disorder, and other mental health conditions associated with impulsiveness.

Family Therapy

Because a person's eating disorder affects the entire family, family therapy can be an important component of recovery. It can help all family members better understand the complex nature of eating disorders, improve their communication skills with one another, and teach strategies for coping with stress and negative feelings. Family-based psychotherapies are also integral parts of nutritional rehabilitation counseling programs, such as the Maudsley approach.

Resources

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Review Date: 3/4/2015
Reviewed By: Timothy Rogge, MD, Medical Director, Family Medical Psychiatry Center, Kirkland, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Author: Julia Mongo, MS.
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